|
KMID : 1036020190080020252
|
|
지질.동맥경화학회지
2019 Volume.8 No. 2 p.252 ~ p.257
|
|
|
Effects of Obesity and Family History of Diabetes on the Association of CETP rs6499861 with HDL-C Level in Korean Populations
|
|
Sull Jae-Woong
Kim Soriul
Jee Sun-Ha
|
|
|
Abstract
|
|
|
Objectives: The aim of this study was to examine the associations of cholesterol ester transfer protein (CETP) rs6499861 and rs12708980 with high-density lipoprotein cholesterol (HDL-C) considering obesity and family history of diabetes (FHD) in Korean men and women.
Methods: We analyzed the association of CETP single nucleotide polymorphisms (SNPs) with HDL-C among individuals selected from a hospital (n=4 294) and the Bundang-gu area in Korea (n=2 304).
Results: We found that the CETP SNP rs6499861 was associated with a lower HDL-C level (effect per allele: ?2.044 mg/dL, p<0.0001). Individuals with a rs6499861 CG/GG genotype had a 1.45-fold higher risk of an abnormal level of HDL-C (<40 mg/dL) than those with a CC genotype. This genotype-HDL-C association was stronger in women (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.39?2.85) compared with men (OR, 1.33; 95% CI, 1.10?1.61) and in women with a FHD (OR, 4.82; 95% CI, 1.86?12.5; p=0.0012) compared with women without a family history. Relative to individuals with a CC genotype and body mass index (BMI) <25.69 kg/m2, individuals with a CG/GG genotype and BMI ≥25.69 kg/m2 had an OR (95% CI) of 2.61 (1.97?3.47).
Conclusions: These findings indicate that CETP variants are linked to HDL-C level in Koreans and that this link is stronger in obese men and in women who have a FHD.
|
|
|
KEYWORD
|
|
|
Cholesterol ester transfer proteins, HDL cholesterol, Physical activity, Genetic polymorphisms
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|